The more action-focused segments from Codename 47 have been removed in favor of entirely stealth-focused missions, though players are free to choose their own style of gameplay. Like its predecessor, gameplay focuses on eliminating targets while trying to remain undetected for as long as possible, may it be by taking disguises, avoiding suspicious enemies, or other means.

Following the events of Codename 47, the former contract killer has retired and started a peaceful life at a church, but after his only friend, Reverend Emilio Vittorio, is kidnapped by unknown assailants, 47 resumes work for the ICA in hopes of tracking him down. The single-player story once again follows Agent 47, a genetically enhanced human clone who worked for the International Contract Agency (ICA) as an assassin. It is the second installment in the Hitman video game series and the sequel to Hitman: Codename 47. The game was re-released for Windows through the Steam online distribution service, and a DRM-free version was later made available through GOG.com. Hitman 2: Silent Assassin is a 2002 stealth video game developed by IO Interactive and published by Eidos Interactive for Microsoft Windows, PlayStation 2, Xbox and GameCube.

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